Journal: Investigative Ophthalmology & Visual Science
Article Title: Targeting MCM6 Enhances Melphalan Chemosensitivity in Retinoblastoma by Modulating DNA Damage Response
doi: 10.1167/iovs.66.15.14
Figure Lengend Snippet: Expression of MCM6 after intravitreal melphalan chemotherapy in human retinoblastoma. ( A , B ) Immunohistochemical staining of MCM6 in human RB tissues from melphalan (Melp)-refractory cases ( A ) and percentage of MCM6 + cells compared with untreated RB tissues ( B ). Data are presented as mean ± SD ( n = 8 for untreated group; n = 6 for melphalan-refractory group), with significance assessed by unpaired two-tailed Student's t -test. ** P < 0.01.
Article Snippet: On day 14 post-injection, mice received a single intravitreal injection of 1-μL melphalan (0.25 μg/μL in PBS, HY-17575; MedChemExpress, Monmouth Junction, NJ, USA) or vehicle.
Techniques: Expressing, Immunohistochemical staining, Staining, Two Tailed Test